Understanding how fat cells regulate energy use
Translational regulation of PGC1alpha and oxidative metabolism
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11136632
This study is looking at how certain fat cells help our bodies burn energy, which could lead to new ways to treat obesity and related health issues, by focusing on a specific molecule that plays a key role in how these cells work.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11136632 on ClinicalTrials.gov |
What this research studies
This research investigates how specific fat cells, known as thermogenic adipocytes, manage energy expenditure to potentially treat obesity and related metabolic diseases. It focuses on the role of a particular mRNA, PPARGC1A, which is crucial for mitochondrial function, and explores how its translation is controlled in these cells. The study employs various methodologies, including protein purification and advanced ribosome profiling, to uncover the mechanisms behind fat cell metabolism. By understanding these processes, the research aims to identify new ways to enhance energy expenditure in fat cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or metabolic disorders.
Not a fit: Patients who do not have obesity or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for obesity and diabetes by improving how fat cells burn energy.
How similar studies have performed: Other research has shown promise in manipulating fat cell metabolism, suggesting that this approach could yield significant insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUMESIC, PHILLIP ANTHONY — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: DUMESIC, PHILLIP ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.