Understanding how fat cells in bone marrow affect multiple myeloma
Research Specialist Support for Defining the Roles of Bone Marrow Adipocytes and FABP4/5 Signaling in Multiple Myeloma
This study is looking at how fat cells in the bone marrow affect the growth of multiple myeloma and why some treatments don't work as well, with the hope of finding new ways to help patients fight this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10893594 on NIH RePORTER |
What this research studies
This research investigates the role of bone marrow fat cells in the progression of multiple myeloma, a type of blood cancer. It aims to uncover how these fat cells interact with myeloma cells and contribute to drug resistance, which is a common challenge for patients. By using advanced three-dimensional tissue models, the study will explore the mechanisms of communication between fat cells and cancer cells, potentially leading to new treatment strategies. The findings could help identify specific vulnerabilities in myeloma that can be targeted for therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple myeloma, particularly those who may be experiencing drug resistance.
Not a fit: Patients with other types of cancers or those without multiple myeloma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options that improve treatment outcomes for patients with multiple myeloma.
How similar studies have performed: While the specific approach of studying the interaction between bone marrow adipocytes and myeloma cells is relatively novel, similar research has shown promise in understanding cancer microenvironments.
Where this research is happening
Portland, United States
- Mainehealth — Portland, United States (Active)
Researchers
- Principal investigator: Campbell, Heather F — Mainehealth
- Study coordinator: Campbell, Heather F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.