Understanding how fat cells generate heat through mitochondria and peroxisomes
Mitochondrial dynamics and the control of adipose tissue thermogenesis
This study is looking at how tiny parts of our cells, called mitochondria and peroxisomes, work together in brown fat to help control body temperature and metabolism, with the hope of finding new ways to treat obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11059096 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondria and peroxisomes in the thermogenic function of brown adipose tissue (BAT), which is important for regulating body temperature and metabolism. By exploring how these organelles interact and their response to adrenergic stimulation, the study aims to uncover new therapeutic strategies for obesity. The research involves advanced techniques such as protein mass spectrometry to analyze the molecular mechanisms at play. Patients may benefit from insights that could lead to new treatments targeting fat metabolism and energy expenditure.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals struggling with obesity or metabolic disorders related to adipose tissue.
Not a fit: Patients who do not have issues related to obesity or metabolic dysfunction may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for obesity by enhancing the body's ability to burn fat.
How similar studies have performed: Previous research has shown promising results in understanding the role of brown fat in metabolism, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Lodhi, Irfan J — Washington University
- Study coordinator: Lodhi, Irfan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.