Understanding how fat cells generate heat and energy
Official title: Regulatory mechanisms of mitochondrial cristae biogenesis and thermogenic function
Funded at Dana-Farber Cancer Inst · NIH-10890156 · Data updated 2026-11-12
This study is looking at how special fat cells can help our bodies burn energy and stay healthy, especially for people dealing with obesity and type 2 diabetes, by seeing if cold temperatures and certain medications can make these cells work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $664,134 |
| NIH project number | 5R01DK136640-02 |
| Project ID | NIH-10890156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are struggling with obesity or type 2 diabetes.
✕Less likely to help
Patients who are not overweight or do not have type 2 diabetes may not benefit from this research.
What this research studies
This research investigates the mechanisms behind how specialized fat cells, known as brown and beige adipocytes, contribute to energy balance and thermogenesis, particularly in the context of obesity and type 2 diabetes. By exploring the role of mitochondrial structures called cristae in these fat cells, the study aims to uncover new ways to enhance metabolic function and combat weight-related health issues. The approach includes examining how cold exposure and certain drugs can activate these fat cells to improve energy expenditure and overall metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to more effective and affordable treatments for obesity and type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in enhancing thermogenic activity in fat cells, indicating that this approach has potential for success.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Puigserver, Pere — Dana-Farber Cancer Inst
- Study coordinator: Puigserver, Pere
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.