Understanding how fat cells develop and affect metabolism
Pcpe2 in Adipose Tissue Expansion and Lipoprotein Metabolism
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11066541
This study is looking at how certain cells that turn into fat cells affect weight gain and diabetes, hoping to find ways to help people manage their weight and improve their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11066541 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific precursor cells in the development of fat tissue and their impact on metabolism, particularly in relation to obesity and type 2 diabetes. By examining how these cells differentiate into mature fat cells and how they respond to dietary influences, the study aims to uncover mechanisms that could lead to healthier fat tissue expansion. The research employs advanced techniques like single-cell sequencing to analyze the behavior of these cells in response to high-fat diets. Patients may benefit from insights that could lead to new treatments for obesity-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are overweight or obese and at risk for developing type 2 diabetes or cardiovascular disease.
Not a fit: Patients who are underweight or have no metabolic disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity and its associated diseases, such as type 2 diabetes and cardiovascular disease.
How similar studies have performed: Other research has shown promising results in understanding fat cell biology and its implications for metabolic health, suggesting that this approach could yield valuable insights.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SORCI-THOMAS, MARY G — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: SORCI-THOMAS, MARY G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.