Understanding how fat cells affect skin scarring
Mechanism and Impact of Dermal adipocyte remodeling in skin fibrosis
This study is looking at how mature fat cells in the skin might help reduce scarring in people with skin fibrosis, and it could lead to new treatments that help heal those affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10797012 on NIH RePORTER |
What this research studies
This research investigates the role of mature fat cells in skin fibrosis, a condition that leads to excessive scarring in various skin disorders. The study focuses on how these fat cells can release fatty acids that may help reduce the production of scar tissue. By using advanced genetic mouse models and laboratory assays, the researchers aim to uncover the mechanisms behind fat cell behavior during fibrosis. This could lead to new personalized therapies that promote healing in patients suffering from skin fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions that cause skin fibrosis, such as systemic sclerosis, keloids, or atopic dermatitis.
Not a fit: Patients without any form of skin fibrosis or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve healing and reduce scarring for patients with skin fibrosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of fat cells in tissue healing, suggesting that this approach may lead to significant advancements.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Horsley, Valerie — Yale University
- Study coordinator: Horsley, Valerie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.