Understanding how fat cell loss occurs in a specific genetic condition
Official title: Mechanisms of adipocyte loss in mouse models of familial partial lipodystrophy 2
Funded at University of Michigan at Ann Arbor · NIH-10866386 · Data updated 2026-11-12
This study is looking at a rare condition called familial partial lipodystrophy 2, which causes fat loss and related health problems, by using specially modified mice to see how a protein called lamin A/C affects fat cells, with the hope of finding new ways to help people with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,099 |
| NIH project number | 5F31DK135181-02 |
| Project ID | NIH-10866386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with familial partial lipodystrophy or similar metabolic conditions.
✕Less likely to help
Patients without any form of lipodystrophy or metabolic dysfunction may not benefit from this research.
What this research studies
This research investigates familial partial lipodystrophy 2, a rare condition characterized by the loss of fat tissue and related metabolic issues. Using mouse models, the study focuses on the role of a specific protein, lamin A/C, in maintaining fat cells. By creating genetically modified mice that can lose this protein, researchers aim to uncover the mechanisms behind fat cell loss and its consequences on metabolism. This work could lead to a better understanding of the disease and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with familial partial lipodystrophy and related metabolic disorders.
How similar studies have gone: While the specific approach in this research is novel, previous studies have shown that understanding genetic mechanisms in similar conditions can lead to significant advancements in treatment.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Maung, Jessica Nanda — University of Michigan at Ann Arbor
- Study coordinator: Maung, Jessica Nanda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.