Understanding how fat cadherins control tissue growth and organization
Dissecting Fat cadherin function in vivo
This study is looking at special proteins called fat cadherins that help cells stick together and grow properly, using fruit flies to see how they work, which could help us understand more about cancer and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10673169 on NIH RePORTER |
What this research studies
This research investigates the role of fat cadherins, which are important proteins that help cells stick together and organize in tissues. Using advanced techniques like CRISPR gene editing in fruit flies, the researchers aim to uncover how these proteins influence growth and maintain symmetry in developing tissues. By tagging these proteins with fluorescent markers, they will identify other proteins that interact with fat cadherins, providing insights into their functions in cell communication and organization. The findings could lead to a better understanding of how disruptions in these processes may contribute to cancer and other diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or conditions related to cell adhesion and tissue organization.
Not a fit: Patients with conditions unrelated to cell adhesion or those not affected by malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer and improving tissue regeneration.
How similar studies have performed: Other research has shown promising results in understanding cell adhesion mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mcneill, Helen — Washington University
- Study coordinator: Mcneill, Helen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.