Understanding how fat buildup affects benign prostate disease
Identifying the role of lipid accumulation and foam cells in benign prostate disease
['FUNDING_R01'] · OLD DOMINION UNIVERSITY · NIH-10981211
This study is looking at how fat buildup and certain immune cells might affect urinary problems in older men with benign prostatic hyperplasia (BPH), and it hopes to find new ways to help manage this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OLD DOMINION UNIVERSITY (nih funded) |
| Locations | 1 site (NORFOLK, UNITED STATES) |
| Trial ID | NIH-10981211 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lipid accumulation and foam cells in benign prostatic hyperplasia (BPH), a condition that causes urinary issues in aging men. By examining clinical samples and using mouse models, the study aims to uncover the relationship between inflammation, fat buildup, and urinary dysfunction. Researchers will explore how specific cytokines influence the immune environment in the prostate and assess the effects of increased lipid synthesis in prostate cells. The goal is to identify new therapeutic strategies for managing BPH.
Who could benefit from this research
Good fit: Ideal candidates for this research are aging males experiencing lower urinary tract symptoms associated with benign prostatic hyperplasia.
Not a fit: Patients who do not have benign prostatic hyperplasia or are not experiencing urinary symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve urinary symptoms and quality of life for men with benign prostatic hyperplasia.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding the cellular mechanisms of BPH can lead to meaningful advancements in treatment.
Where this research is happening
NORFOLK, UNITED STATES
- OLD DOMINION UNIVERSITY — NORFOLK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POPOVICS, PETRA — OLD DOMINION UNIVERSITY
- Study coordinator: POPOVICS, PETRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.