Understanding how fat accumulation in the colon affects tumor growth in obesity
Regulation of DGAT - dependent lipogenesis in colonic epithelial growth
This study is looking at how fat storage in the colon might lead to colon cancer, especially in people who are obese, and it hopes to find new ways to treat this cancer by understanding how obesity affects cancer risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11051775 on NIH RePORTER |
What this research studies
This research investigates the role of lipid droplets in the colon and how their accumulation, particularly in obese individuals, may contribute to the development of colon cancer. The study focuses on a specific regulatory network involving acyltransferases that mediate fat production and its impact on tumor growth. By examining the relationship between obesity, inflammation, and tumorigenesis, the research aims to uncover critical mechanisms that could lead to new treatment options for colon cancer. Patients may benefit from insights gained about how obesity influences cancer risk and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and at risk for colon cancer.
Not a fit: Patients who are not obese or do not have a history of colon-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colon cancer in obese patients.
How similar studies have performed: Other research has shown promising results in understanding the link between obesity and cancer, making this approach both relevant and potentially impactful.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Savkovic, Suzana D. — Tulane University of Louisiana
- Study coordinator: Savkovic, Suzana D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.