Understanding how fast heart rates affect heart function
Official title: Tachycardia-induced Metabolic Remodeling Drives Cardiac Dysfunction
Funded at Stanford University · NIH-10906100 · Data updated 2026-11-12
This study is looking at how fast heart rates affect heart function and what happens at the cellular level, with the goal of finding better treatments for people with heart failure caused by tachycardia.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $151,637 |
| NIH project number | 5K99HL164962-02 |
| Project ID | NIH-10906100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing tachycardia, particularly those with heart failure or no prior structural heart disease.
✕Less likely to help
Patients with stable heart conditions that do not involve tachycardia may not benefit from this research.
What this research studies
This research investigates the effects of tachycardia, or abnormally fast heart rates, on heart function and the underlying molecular mechanisms that lead to cardiac dysfunction. By utilizing advanced techniques such as induced pluripotent stem cells and engineered heart tissue, the study aims to identify critical signaling pathways involved in heart disease related to tachycardia. The research will involve profiling metabolic and genetic changes in heart tissues exposed to rapid pacing, as well as validating findings with canine heart samples. This approach seeks to fill a significant knowledge gap that could lead to better treatments for patients suffering from heart failure exacerbated by tachycardia.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with heart failure and tachycardia, potentially enhancing their quality of life and reducing cardiovascular risks.
How similar studies have gone: Previous research has shown promise in understanding cardiac dysfunction through similar methodologies, indicating potential for success in this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Tu, Chengyi — Stanford University
- Study coordinator: Tu, Chengyi
Related research
Other NIH-funded projects on the same topics.
-
Map heart tissue to guide VT ablation with AI help
A patient-oriented project aims to use AI-based mapping to better identify abnormal heart tissue responsible for ventricular tachycardia and guide safer, faster ablation.
-
Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
-
Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
-
Novel gene therapy tools to prevent dangerous heart rhythms
A small grant supports testing gene-therapy methods to stop ventricular tachycardia after a heart attack, with the goal of helping people at risk of sudden heart rhythm problems.
-
Understanding different types of POTS to tailor treatments
A research project is studying why people with POTS have different symptoms and how to personalize exercise-based treatment.
-
GIP and blood pooling in the gut: a potential driver of POTS symptoms
This NIH grant studies how a glucose-driven hormone affects blood flow and heart rate in adults with Postural Tachycardia Syndrome to explain why meals can worsen symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.