Understanding how fast heart rates affect heart function
Tachycardia-induced Metabolic Remodeling Drives Cardiac Dysfunction
This study is looking at how fast heart rates affect heart function and what happens at the cellular level, with the goal of finding better treatments for people with heart failure caused by tachycardia.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10906100 on NIH RePORTER |
What this research studies
This research investigates the effects of tachycardia, or abnormally fast heart rates, on heart function and the underlying molecular mechanisms that lead to cardiac dysfunction. By utilizing advanced techniques such as induced pluripotent stem cells and engineered heart tissue, the study aims to identify critical signaling pathways involved in heart disease related to tachycardia. The research will involve profiling metabolic and genetic changes in heart tissues exposed to rapid pacing, as well as validating findings with canine heart samples. This approach seeks to fill a significant knowledge gap that could lead to better treatments for patients suffering from heart failure exacerbated by tachycardia.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing tachycardia, particularly those with heart failure or no prior structural heart disease.
Not a fit: Patients with stable heart conditions that do not involve tachycardia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with heart failure and tachycardia, potentially enhancing their quality of life and reducing cardiovascular risks.
How similar studies have performed: Previous research has shown promise in understanding cardiac dysfunction through similar methodologies, indicating potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Tu, Chengyi — Stanford University
- Study coordinator: Tu, Chengyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.