Understanding how eye tissue develops and repairs itself
Official title: Elucidating signaling networks in Anterior Segment development, repair and diseases
Funded at Johns Hopkins University · NIH-10917282 · Data updated 2026-11-12
This study is looking at how certain cells in the eye develop and heal, especially for people with eye problems like Anterior Segment Dysgenesis, which can cause serious issues like glaucoma, to help find new treatments that could improve vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $410,687 |
| NIH project number | 5R01EY035337-02 |
| Project ID | NIH-10917282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Anterior Segment Dysgenesis or related eye disorders.
✕Less likely to help
Patients with eye conditions unrelated to anterior segment development or repair may not benefit from this research.
What this research studies
This research investigates the cellular and molecular mechanisms involved in the development and repair of the anterior segment of the eye, which is crucial for vision. It focuses on a group of eye disorders known as Anterior Segment Dysgenesis (ASD), which can lead to severe conditions like glaucoma and corneal opacity. By studying the role of primary cilia in neural crest-derived cells, the research aims to uncover how these cells respond to developmental signals and contribute to the formation and healing of eye tissues. Patients may benefit from insights that could lead to new treatments for these debilitating eye disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for congenital eye disorders that cause vision impairment.
How similar studies have gone: Previous research has shown promising results in understanding similar signaling pathways in other developmental disorders, suggesting potential for success in this area.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Iomini, Carlo — Johns Hopkins University
- Study coordinator: Iomini, Carlo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.