Understanding how eye growth leads to myopia
Mechanisms of axial elongation in myopia
This study is looking into how a substance called all-trans retinoic acid affects eye growth in people with myopia, or nearsightedness, to help find better ways to stop or slow down the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11045080 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind myopia, a condition where the eye grows too long, causing vision problems. It focuses on the role of all-trans retinoic acid (atRA) in the signaling pathways that influence eye growth and shape. By using animal models and advanced engineering tools, the study aims to uncover how atRA affects the remodeling of eye tissues, which is crucial for developing effective treatments to prevent or halt myopia progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of developing high myopia or those already diagnosed with myopia.
Not a fit: Patients with stable vision or those who do not have myopia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that prevent or slow the progression of myopia, reducing the risk of severe vision impairment.
How similar studies have performed: Previous research has shown promising results in understanding the role of molecular signaling in eye growth, making this approach a continuation of established findings.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Pardue, Machelle T. — Emory University
- Study coordinator: Pardue, Machelle T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.