Understanding how extracellular RNA carriers affect substance use disorders and HIV infection
Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection
['FUNDING_R21'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11089504
This study is looking at how tiny RNA carriers from bacteria in your gut might affect communication between your gut and brain, especially in relation to issues like substance use disorders and HIV, and it involves patients sharing samples or information to help us understand these connections better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11089504 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular RNA carriers, particularly those from bacteria, in the communication between the gut microbiome and the central nervous system. It aims to explore how these carriers may influence conditions like substance use disorders and HIV infection by modulating gut-brain interactions. The study will utilize both preclinical models and clinical data to identify the mechanisms through which these carriers operate, potentially revealing new pathways for treatment. Patients may be involved in providing samples or data to help elucidate these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with substance use disorders or HIV infection, as well as healthy volunteers for comparative analysis.
Not a fit: Patients with conditions unrelated to substance use or HIV, or those not willing to participate in research, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing substance use disorders and HIV infection.
How similar studies have performed: While the specific approach of studying extracellular RNA carriers in this context is relatively novel, there is emerging evidence supporting the gut-brain axis's role in various health conditions.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROY, SABITA — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: ROY, SABITA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus, Alzheimer disease dementia