Understanding how extra centrosomes affect cell growth and cancer development
Supernumerary Centrosomes and Cell Proliferation
This study is looking at how extra centrosomes in cells can cause them to grow uncontrollably and lead to cancer, and it aims to find out which proteins and pathways help these cells keep dividing, which could help us understand cancer better and improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11064769 on NIH RePORTER |
What this research studies
This research investigates the role of supernumerary centrosomes in cell proliferation and cancer progression. It focuses on how the duplication of centrioles, which are essential for cell division, can lead to abnormal cell growth and tumor formation. By conducting a genome-wide screen, the study aims to identify specific proteins and pathways that allow cells with extra centrosomes to continue dividing, potentially leading to new insights into cancer biology and treatment. Patients may benefit from a better understanding of how these cellular mechanisms contribute to cancer, which could inform future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers associated with centrosome abnormalities or those at risk for such conditions.
Not a fit: Patients with cancers unrelated to centrosome dysfunction or those with early-stage benign conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer treatment by targeting the mechanisms that allow cancer cells with extra centrosomes to proliferate.
How similar studies have performed: Other research has shown promising results in understanding the role of centrosomes in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Glover, David M — California Institute of Technology
- Study coordinator: Glover, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.