Understanding how exosomes communicate and protect heart cells
Molecular identity of exosomal BK channels
This study is looking at tiny particles called exosomes that help cells talk to each other, especially focusing on how they might protect heart cells during times when blood flow is low, which could help people with heart conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10984964 on NIH RePORTER |
What this research studies
This research investigates the role of exosomes, small vesicles that facilitate communication between cells, particularly focusing on their potassium channels known as BK channels. The study aims to understand how these exosomes function in different ionic environments and whether they can protect heart cells from damage caused by reduced blood flow. Using advanced techniques, the researchers will explore the presence and functionality of BK channels in exosomes and their potential protective effects on heart tissue during ischemic events. Patients may benefit from insights gained about exosomes as potential therapeutic targets for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions, particularly those at risk for ischemia or related injuries.
Not a fit: Patients with non-cardiac conditions or those not experiencing ischemic events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from damage during ischemic events.
How similar studies have performed: Other research has shown promise in understanding exosomal functions and their potential therapeutic roles, suggesting that this approach may yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Singh, Harpreet — Ohio State University
- Study coordinator: Singh, Harpreet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.