Understanding how exhausted CD8 T cells respond to cancer treatment
Role of progenitor exhausted CD8 T cells and the progenitor niche in anti-PD1 efficacy
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10909191
This study is looking at how tired immune cells called CD8 T cells respond to a cancer treatment called anti-PD-1, to understand why some patients feel better but don't fully recover, with the hope of finding ways to make treatments work better for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10909191 on ClinicalTrials.gov |
What this research studies
This research investigates the behavior of exhausted CD8 T cells in response to anti-PD-1 therapy, which is a treatment used to help the immune system fight cancer. The study aims to uncover why many patients experience T cell reinvigoration but do not achieve a complete cure. By examining the different types of exhausted T cells, particularly progenitor exhausted T cells, the research seeks to identify the mechanisms that influence their effectiveness in combating tumors. Patients may benefit from insights that could lead to improved treatment strategies and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing anti-PD-1 therapy who exhibit signs of T cell exhaustion.
Not a fit: Patients who are not receiving anti-PD-1 therapy or those with non-exhausted T cell profiles may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of cancer immunotherapy, leading to higher cure rates for patients.
How similar studies have performed: Previous research has shown promising results in understanding T cell dynamics in cancer therapy, indicating that this approach builds on established findings.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, ALEXANDER — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: HUANG, ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.