Understanding how exercise signals improve health
A biochemical roadmap of exercise signal
['FUNDING_OTHER'] · BROAD INSTITUTE, INC. · NIH-11163208
This research explores how exercise helps prevent and treat heart and metabolic conditions by looking at a special molecule called BAIBA.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROAD INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11163208 on ClinicalTrials.gov |
What this research studies
We know exercise is great for preventing and treating heart and metabolic diseases, but we don't fully understand all the ways it helps. Our team found a natural molecule called BAIBA that increases with exercise and appears to improve how the body handles sugar and manages weight in animal models. In people, higher levels of BAIBA in the blood are connected to a lower risk of metabolic problems. This work aims to create a detailed map of these exercise-related signals to uncover new ways to improve health.
Who could benefit from this research
Good fit: This research is relevant for individuals interested in the mechanisms behind exercise's benefits, especially those with or at risk for cardiometabolic diseases.
Not a fit: Patients whose conditions are unrelated to cardiometabolic health or exercise's metabolic effects may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or strategies that mimic the health benefits of exercise for conditions like diabetes and heart disease.
How similar studies have performed: While the general benefits of exercise are well-known, this research explores novel molecular signals like BAIBA, building upon initial findings that show promise in animal models and human observations.
Where this research is happening
CAMBRIDGE, UNITED STATES
- BROAD INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GERSZTEN, ROBERT E — BROAD INSTITUTE, INC.
- Study coordinator: GERSZTEN, ROBERT E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.