Understanding how exercise helps older adults with insulin resistance
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
This study is looking at how different kinds of exercise, like high-energy workouts and strength training, can help older adults aged 60 to 85 with insulin resistance feel better both physically and mentally over six months.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10977567 on NIH RePORTER |
What this research studies
This research investigates how different types of exercise, specifically high-intensity aerobic interval training and resistance training, can improve insulin sensitivity and cognitive function in older adults aged 60 to 85 who have insulin resistance. Participants will engage in a six-month exercise program, and researchers will measure changes in brain metabolism, connectivity, and glucose uptake using advanced imaging techniques. The study aims to clarify the benefits of exercise on both physical and mental health in this population.
Who could benefit from this research
Good fit: Ideal candidates are older adults aged 60 to 85 who are insulin resistant and looking to improve their health through exercise.
Not a fit: Patients who are not insulin resistant or those who are unable to participate in exercise due to severe health limitations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise recommendations that enhance both metabolic health and cognitive function in older adults.
How similar studies have performed: Previous research has shown promising results regarding the benefits of exercise on insulin sensitivity and cognitive function, suggesting that this approach is both relevant and potentially impactful.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Nair, K Sreekumaran — Mayo Clinic Rochester
- Study coordinator: Nair, K Sreekumaran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.