Understanding how exercise can reduce chemotherapy side effects in colon cancer patients based on their biological age.
Characterizing the Risk of Chemotherapy Side Effects Based on Epigenetic Age and Modification by Resistance Training Intervention
This study is looking at how getting older on a biological level affects the side effects of chemotherapy in colon cancer patients, and it’s testing whether resistance training can help reduce those side effects by building muscle, making the treatment experience better for you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-10810538 on NIH RePORTER |
What this research studies
This research investigates the relationship between biological aging and the side effects of chemotherapy in colon cancer patients. It focuses on how resistance training can help mitigate these side effects by increasing muscle mass and potentially reducing the risks associated with chemotherapy. The study will measure biological age through blood samples and assess how this age correlates with chemotherapy toxicity and patient outcomes. By exploring these connections, the research aims to provide insights into improving treatment experiences for patients undergoing chemotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are colon cancer patients who are undergoing chemotherapy and may be experiencing or at risk for muscle loss and related complications.
Not a fit: Patients who are not undergoing chemotherapy or those with other types of cancer unrelated to colon cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to tailored exercise interventions that significantly reduce chemotherapy-related side effects and improve overall patient outcomes.
How similar studies have performed: Previous research has shown that exercise interventions can improve outcomes for cancer patients, suggesting that this approach may be effective, though the specific focus on epigenetic aging in colon cancer is relatively novel.
Where this research is happening
Honolulu, United States
- University of Hawaii at Manoa — Honolulu, United States (Active)
Researchers
- Principal investigator: Binder, Alexandra Margaret Lynn — University of Hawaii at Manoa
- Study coordinator: Binder, Alexandra Margaret Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.