Understanding how exercise affects pain in people with knee osteoarthritis
Project 1: Impaired Exercise Induced Hypoalgesia
['FUNDING_OTHER'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-11056749
This study is looking at why some people with knee osteoarthritis feel more pain instead of relief when they exercise, and it aims to find out how the body’s nervous system and heart rate might play a role, so we can create better exercise programs for those who struggle with traditional workouts.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11056749 on ClinicalTrials.gov |
What this research studies
This research investigates how some individuals with knee osteoarthritis experience increased pain instead of relief when exercising, a phenomenon known as impaired exercise-induced hypoalgesia (EIH). The study aims to uncover the biological mechanisms behind this response by examining factors such as nervous system sensitivity and heart rate variability. By understanding these mechanisms, the research seeks to improve exercise interventions for those who do not benefit from traditional physical activity approaches. Participants will undergo assessments to evaluate their pain responses and nervous system function during exercise.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from knee osteoarthritis and experience chronic pain.
Not a fit: Patients with knee osteoarthritis who do not experience pain or have other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective exercise programs that alleviate pain for individuals with knee osteoarthritis.
How similar studies have performed: Previous research has shown that understanding the neurobiological mechanisms of pain can lead to improved treatment strategies, suggesting potential success for this approach.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEOGI, TUHINA — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: NEOGI, TUHINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.