Understanding how exercise affects insulin's ability to lower blood sugar in muscles
Official title: Regulation of Elevated Postexercise Insulin-stimulated Glucose Uptake by Skeletal Muscle
Funded at University of Michigan at Ann Arbor · NIH-10876537 · Data updated 2026-11-12
This study is looking at how exercise helps insulin work better in muscles to control blood sugar, which is important for people with type 2 diabetes, and it will use a special rat model to learn more about the proteins involved in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $562,214 |
| NIH project number | 1R01DK136700-01A1 |
| Project ID | NIH-10876537 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes or prediabetes who may benefit from improved insulin action.
✕Less likely to help
Patients who do not have insulin resistance or those with type 1 diabetes may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which exercise enhances the ability of insulin to promote glucose uptake in skeletal muscle, which is crucial for managing type 2 diabetes. The study will utilize a unique rat model to explore the role of specific proteins that interact with a key regulator of glucose transport, AS160. By using adeno-associated virus vectors, researchers aim to identify how these proteins influence insulin's effectiveness in muscle tissue after exercise. This could lead to new insights into improving insulin sensitivity and glucose management in patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for type 2 diabetes by enhancing insulin sensitivity in skeletal muscle.
How similar studies have gone: Previous research has shown promising results in understanding insulin signaling and glucose uptake mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Cartee, Gregory D. — University of Michigan at Ann Arbor
- Study coordinator: Cartee, Gregory D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.