Understanding how exercise affects fatigue in people with diabetes

Mechanisms of Fatigability and the Protective Effects of Exercise in People with Diabetes

NIH-funded research Marquette University · NIH-10912519

This study is looking at why people with pre-diabetes and type 2 diabetes feel more tired when they exercise, focusing on how blood flow and oxygen delivery to their muscles might play a role, and it aims to find ways to help them feel better and perform better during workouts.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMarquette University NIH-funded
Lab location1 site (Milwaukee, United States)
Project IDNIH-10912519 on NIH RePORTER

What this research studies

This research investigates the reasons behind increased fatigue during exercise in individuals with pre-diabetes and type 2 diabetes. It focuses on how impaired blood flow and oxygen delivery to muscles may contribute to this fatigue. By examining the vascular responses during exercise, the study aims to identify mechanisms that could help improve exercise performance and overall health in these individuals. Participants may engage in exercise training while their vascular function is monitored.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with pre-diabetes or type 2 diabetes.

Not a fit: Patients who do not have pre-diabetes or type 2 diabetes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved exercise strategies that enhance physical performance and health outcomes for individuals with diabetes.

How similar studies have performed: Previous research has shown that exercise can significantly improve health outcomes in individuals with diabetes, suggesting that this approach may yield beneficial results.

Where this research is happening

Milwaukee, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Adult-Onset Diabetes Mellitus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.