Understanding how excitability issues contribute to ALS and FTD.
Official title: Excitability dysfunction mechanisms underlying the TDP43-dependent ALS and FTD pathogenesis
Funded at Wright State University · NIH-11054719 · Data updated 2026-11-12
This study is looking at how nerve cells behave in people with ALS and frontotemporal dementia, using special mouse models to figure out if changes in these cells are helping or hurting, which could lead to better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $79,238 |
| NIH project number | 3R01NS131816-02S1 |
| Project ID | NIH-11054719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ALS or FTD, particularly those with sporadic onset.
✕Less likely to help
Patients with other neurodegenerative diseases unrelated to ALS or FTD may not benefit from this research.
What this research studies
This research investigates the mechanisms of excitability dysfunction in motoneurons related to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). By utilizing advanced mouse models that mimic the disease pathology, the study aims to clarify conflicting findings regarding motoneuron excitability changes. The researchers will explore whether these excitability changes are protective or harmful, which could lead to better understanding and potential treatments for ALS and FTD. Patients may benefit from insights gained into the disease mechanisms that could inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for ALS and FTD.
How similar studies have gone: While there has been significant research on excitability in ALS, this specific approach using the rNLS8 mouse model is novel and has not been extensively tested.
Where this research is happening
-
Wright State University
Dayton, United States Active
Researchers
- Principal investigator: Elbasiouny, Sherif M — Wright State University
- Study coordinator: Elbasiouny, Sherif M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.