Understanding how excess manganese affects brain function and movement
Identifying neuronal targets and mechanisms of manganese-induced neuromotor disease
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10998783
This study is looking at how too much manganese can harm the brain and affect movement and thinking skills, using special mice to learn more about the brain cells involved, which could help find better ways to treat people exposed to high levels of manganese.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10998783 on ClinicalTrials.gov |
What this research studies
This research investigates the harmful effects of excess manganese on the brain, particularly focusing on how it impacts motor skills and cognitive abilities. The study uses specialized mouse models to explore the specific neurons affected by manganese toxicity, particularly those in the basal ganglia, which are crucial for movement control. By examining the role of a specific protein involved in manganese transport, the research aims to uncover the underlying mechanisms of manganese-induced neuromotor diseases. This could lead to better understanding and potential treatments for individuals exposed to high levels of manganese.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to high levels of manganese, either environmentally or occupationally, and are experiencing motor or cognitive deficits.
Not a fit: Patients who have not been exposed to manganese or do not exhibit any related neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating motor and cognitive deficits caused by manganese exposure.
How similar studies have performed: Previous studies have shown that understanding the mechanisms of neurotoxicity can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELKOTE, ASHVINI — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: MELKOTE, ASHVINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.