Understanding how excess fats harm kidney cells
Official title: Mechanisms of Renal Lipotoxicity
Funded at Broad Institute, INC. · NIH-10824920 · Data updated 2026-11-12
This study is looking at how too much fat in the body can harm kidney cells and lead to chronic kidney disease, with the goal of finding new ways to help treat this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,574 |
| NIH project number | 1F31DK136312-01A1 |
| Project ID | NIH-10824920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of or currently suffering from chronic kidney disease.
✕Less likely to help
Patients with acute kidney injury or those whose kidney function is not affected by lipid accumulation may not benefit from this research.
What this research studies
This research investigates the harmful effects of excess lipids, specifically free fatty acids, on kidney cells, which can lead to chronic kidney disease (CKD). The study aims to uncover the cellular mechanisms behind lipotoxicity and its role in kidney damage, potentially identifying new therapeutic targets. The research will utilize advanced techniques, including CRISPR-based screening, to explore how these lipids induce cell death and fibrosis in kidney tissues. By enhancing our understanding of these processes, the research seeks to pave the way for innovative treatments for CKD.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or slow the progression of chronic kidney disease.
How similar studies have gone: Previous research has shown promise in understanding lipid-induced cellular damage in other contexts, suggesting that this approach may yield valuable insights for kidney disease as well.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Gabriel, Katlyn Rose — Broad Institute, INC.
- Study coordinator: Gabriel, Katlyn Rose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.