Understanding how EV-D68 virus affects the nervous system in children
Official title: Genomic and molecular determinants of EV-D68 neuroinvasive disease
Funded at University of Colorado Denver · NIH-11096086 · Data updated 2026-11-12
This study is looking at how the EV-D68 virus affects the nervous system in kids under 11, with the goal of finding better ways to treat and prevent serious conditions like acute flaccid myelitis, and it may involve kids providing samples or information to help us learn more.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $388,750 |
| NIH project number | 5R01AI171275-03 |
| Project ID | NIH-11096086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children under 11 years old who have experienced symptoms related to EV-D68 or acute flaccid myelitis.
✕Less likely to help
Patients over the age of 11 or those without a history of EV-D68 infection or related neurological symptoms may not benefit from this research.
What this research studies
This research investigates the genomic and molecular factors that contribute to the neuroinvasive disease caused by the EV-D68 virus, particularly in children under 11 years old. The study aims to enhance our understanding of how this virus can lead to severe neurological conditions, such as acute flaccid myelitis. By analyzing viral infections and their impact on the central nervous system, the research seeks to identify potential new treatments and preventive measures. Patients may be involved in providing samples or data to help elucidate the mechanisms of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for children affected by EV-D68 and similar viral infections.
How similar studies have gone: Previous research on enteroviruses has shown promise in understanding their impact on the nervous system, but this specific approach to EV-D68 is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Tyler, Kenneth L. — University of Colorado Denver
- Study coordinator: Tyler, Kenneth L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.