Understanding how eukaryotic cells manage their organelles and growth.
The design principles of the eukaryotic cell: uncovering the coordination of systems-level organelle dynamics, metabolism and growth
This study is looking at how cells manage their tiny parts, called organelles, to help them grow and stay healthy, using special imaging tools and math to see how these parts change when the cell needs more energy or resources.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10890623 on NIH RePORTER |
What this research studies
This research investigates the intricate organization of eukaryotic cells, focusing on how they regulate the size, number, and positioning of organelles to support growth and metabolism. By employing advanced imaging techniques and mathematical modeling, the project aims to quantify the relationship between organelle dynamics and cellular growth demands. The approach includes visualizing metabolic organelles and manipulating cellular conditions to observe their effects on growth and gene expression. This comprehensive analysis could provide insights into fundamental cellular processes that are crucial for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular growth and metabolism, including cancer and metabolic disorders.
Not a fit: Patients with non-cellular related conditions or those not experiencing issues with cell growth or metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cell growth and metabolism, such as cancer and diabetes.
How similar studies have performed: Other research has shown success in understanding cellular dynamics and organelle function, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mukherji, Arindam Shankar — Washington University
- Study coordinator: Mukherji, Arindam Shankar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.