Understanding how estrogen therapy works for advanced breast cancer

Who could benefit from this research

What this research studies

This research investigates why some advanced breast cancers that are positive for estrogen receptors respond well to estrogen therapy while others do not. The project aims to uncover the mechanisms that influence how breast cancer cells react to estrogen, specifically focusing on the hormone 17b-estradiol. By examining the effects of this hormone on cancer cell behavior and the role of specific mutations, the research seeks to develop tailored treatment strategies that could improve patient outcomes. Patients may benefit from a more personalized approach to their estrogen therapy based on their tumor characteristics.

Why it matters

Where this research is happening

• Medical College of Wisconsin
  Milwaukee, United States Active

Researchers

• Principal investigator: Miller, Todd W. — Medical College of Wisconsin
• Study coordinator: Miller, Todd W.

Related research

Other NIH-funded projects on the same topics.

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  A Mayo Clinic team is testing advanced computer-derived features from 3D mammograms to improve predicting who will develop breast cancer, including diverse groups of women.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11386848

• Improving how the immune system fights advanced breast cancer by relieving tumor pressure

  A breast cancer treatment study tests whether a common blood pressure drug (losartan) can help immune cells get into tumors and work better with immunotherapy.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11379056

• Using a blood test that looks for tumor DNA to monitor early and locally advanced breast cancer

  This project uses a sensitive blood test that looks for tiny bits of tumor DNA to track treatment response in people with early or locally advanced breast cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11306078

• Personalizing estrogen therapy for ER-positive breast cancer

  This project finds how the hormone estrogen can kill certain ER-positive breast cancers and how to tell which patients will benefit.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11304574

• Longer overnight fasting and exercise to reduce fatigue in women with hormone receptor–positive advanced breast cancer

  This project will see if longer overnight fasting and regular exercise help women with hormone receptor–positive advanced breast cancer feel less fatigued and improve their quality of life.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11176126

• FFNP-PET scans to predict hormone therapy response in advanced ER-positive breast cancer

  This project uses a special PET scan called FFNP to find which people with ER-positive, HER2-negative advanced breast cancer are likely to benefit from hormone (endocrine) therapies.

  NIH research Washington University · Saint Louis, United States · NIH-11172663

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.