Understanding how estrogen therapy works for advanced breast cancer
A precision medicine basis for estrogen therapy for advanced breast cancer
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11059927
This study is looking into why some advanced breast cancers that have estrogen receptors respond well to estrogen therapy while others don’t, with the goal of finding better, personalized treatment options for patients based on their specific tumor traits.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11059927 on ClinicalTrials.gov |
What this research studies
This research investigates why some advanced breast cancers that are positive for estrogen receptors respond well to estrogen therapy while others do not. The project aims to uncover the mechanisms that influence how breast cancer cells react to estrogen, specifically focusing on the hormone 17b-estradiol. By examining the effects of this hormone on cancer cell behavior and the role of specific mutations, the research seeks to develop tailored treatment strategies that could improve patient outcomes. Patients may benefit from a more personalized approach to their estrogen therapy based on their tumor characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced breast cancer that is estrogen receptor positive.
Not a fit: Patients with breast cancer that is not estrogen receptor positive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized estrogen therapies for patients with advanced breast cancer.
How similar studies have performed: Other research has shown promise in understanding the mechanisms of hormone therapy in breast cancer, suggesting that this approach could yield significant insights.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, TODD W. — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: MILLER, TODD W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: advanced breast cancer, advanced stage breast cancer, anti-cancer