Understanding how estrogen receptors affect insulin-producing cells in diabetes
Official title: The Role of G Protein-Coupled Estrogen Receptor Signaling in the Maintenance of Beta Cell Identity
Funded at Purdue University · NIH-11042699 · Data updated 2026-11-12
This study is looking at how certain estrogen receptors help keep insulin-producing cells in your pancreas healthy and working properly, which is important for managing blood sugar levels, and it hopes to find new ways to help people with type 2 diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30DK137559-02 |
| Project ID | NIH-11042699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those experiencing challenges with insulin secretion.
✕Less likely to help
Patients with type 1 diabetes or those whose diabetes is not related to beta cell dysfunction may not benefit from this research.
What this research studies
This research investigates the role of G protein-coupled estrogen receptors in maintaining the identity and function of insulin-producing beta cells, which are crucial for regulating blood sugar levels. The study focuses on how these receptors influence calcium signaling in beta cells and how their dysfunction may contribute to type 2 diabetes. By examining the molecular mechanisms behind beta cell dedifferentiation, the research aims to uncover potential therapeutic targets for improving insulin secretion in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance insulin production and improve blood sugar control in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of estrogen receptors in metabolic processes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Mclaughlin, Madeline Rae — Purdue University
- Study coordinator: Mclaughlin, Madeline Rae
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.