Understanding how estrogen receptor signaling affects breast cancer treatment
Mechanisms of estrogen receptor ligand signaling
This study is looking at how certain treatments for breast cancer work and why some patients stop responding to them, with a special focus on a new type of medication that might help those whose cancer is tough to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11079550 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of estrogen receptor signaling in breast cancer, particularly focusing on how different treatments can lead to resistance in patients. It explores the use of dual mechanism estrogen receptor inhibitors (DMERI) that may provide effective alternatives for patients whose cancers do not respond to standard therapies. By studying the interactions between estrogen receptors and various treatment modalities, the research aims to identify new therapeutic strategies for patients with estrogen receptor-positive breast cancer. The approach includes both laboratory experiments and analysis of patient samples to understand the underlying biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with estrogen receptor-positive breast cancer, particularly those who have shown resistance to current therapies.
Not a fit: Patients with estrogen receptor-negative breast cancer or those who have not received prior treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with resistant forms of breast cancer.
How similar studies have performed: Previous research has shown promise in targeting estrogen receptors with novel inhibitors, indicating potential for success in this area.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Nettles, Kendall W — University of Florida
- Study coordinator: Nettles, Kendall W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.