Understanding how estrogen receptor beta affects endometriosis
The Genomic Function of Estrogen Receptor Beta in Endometriosis
This study is looking at how a specific protein called estrogen receptor beta (ERβ) affects endometriosis, which is a condition linked to estrogen, using a special mouse model, to find new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10755321 on NIH RePORTER |
What this research studies
This research investigates the role of estrogen receptor beta (ERβ) in the development and progression of endometriosis, a condition influenced by estrogen. The study utilizes a unique mouse model to explore how ERβ regulates gene expression and cell survival in endometriotic tissues. By examining the interactions between ERβ and various cellular pathways, the research aims to uncover mechanisms that contribute to the disease's persistence and severity. Patients may benefit from insights that could lead to new therapeutic strategies targeting ERβ.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with endometriosis who are experiencing symptoms related to the condition.
Not a fit: Patients without endometriosis or those whose symptoms are unrelated to estrogen signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or alleviate the symptoms of endometriosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of estrogen receptors in other estrogen-dependent conditions, suggesting potential for success in this area as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Han, Sang Jun — Baylor College of Medicine
- Study coordinator: Han, Sang Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.