Understanding how estrogen influences cell growth through mTOR signaling
Official title: Estrogenic signaling upstream and downstream of mTOR
Funded at New York Medical College · NIH-10470830 · Data updated 2026-11-12
This study is looking at how estrogen affects cell growth and function, which is important for understanding diseases related to estrogen, and it aims to find out how estrogen activates a key pathway in our cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $410,000 |
| NIH project number | 5R35GM128675-05 |
| Project ID | NIH-10470830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions influenced by estrogen, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to estrogen signaling or mTOR pathways may not benefit from this research.
What this research studies
This research investigates the interaction between estrogen signaling and the mTOR pathway, which are crucial for regulating cell growth and proliferation. The team will explore how estrogen activates mTOR and identify the specific cellular processes that follow this activation. Using advanced techniques like quantitative proteomics and RNA sequencing, the study aims to uncover new insights into how estrogen affects protein synthesis and cellular function. This research is particularly relevant for understanding diseases that are influenced by estrogen.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for estrogen-dependent diseases by targeting the mTOR pathway.
How similar studies have gone: Previous research has shown promising results in understanding the roles of estrogen in cellular signaling, indicating that this approach has potential for success.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Holz, Marina K — New York Medical College
- Study coordinator: Holz, Marina K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.