Understanding how estrogen affects high blood pressure in postmenopausal women
Unraveling the Impact of Estrogen Signaling on Postmenopausal Hypertension
This study is looking at how estrogen affects blood pressure after menopause, using specially modified mice to understand the details, and it hopes to find new ways to help women manage high blood pressure during this time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11115588 on NIH RePORTER |
What this research studies
This research investigates the role of estrogen signaling in the development of high blood pressure after menopause. It focuses on how estrogen interacts with specific receptors in the body, particularly the G protein-coupled estrogen receptor 1 (GPER1), and its effects on blood pressure regulation. By studying genetically modified mice, the research aims to uncover the molecular mechanisms behind postmenopausal hypertension, which could lead to new treatment strategies. Patients may benefit from insights that could improve management of hypertension related to menopause.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women experiencing hypertension.
Not a fit: Patients who are premenopausal or do not have hypertension may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage high blood pressure in postmenopausal women.
How similar studies have performed: Previous research has shown promising results in understanding estrogen's role in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Gohar, Eman — Vanderbilt University Medical Center
- Study coordinator: Gohar, Eman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.