Understanding how estrogen affects high blood pressure in postmenopausal women
Official title: Unraveling the Impact of Estrogen Signaling on Postmenopausal Hypertension
Funded at Vanderbilt University Medical Center · NIH-11115588 · Data updated 2026-11-12
This study is looking at how estrogen affects blood pressure after menopause, using specially modified mice to understand the details, and it hopes to find new ways to help women manage high blood pressure during this time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 7, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $538,992 |
| NIH project number | 5R01HL171122-02 |
| Project ID | NIH-11115588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women experiencing hypertension.
✕Less likely to help
Patients who are premenopausal or do not have hypertension may not receive benefit from this research.
What this research studies
This research investigates the role of estrogen signaling in the development of high blood pressure after menopause. It focuses on how estrogen interacts with specific receptors in the body, particularly the G protein-coupled estrogen receptor 1 (GPER1), and its effects on blood pressure regulation. By studying genetically modified mice, the research aims to uncover the molecular mechanisms behind postmenopausal hypertension, which could lead to new treatment strategies. Patients may benefit from insights that could improve management of hypertension related to menopause.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage high blood pressure in postmenopausal women.
How similar studies have gone: Previous research has shown promising results in understanding estrogen's role in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Gohar, Eman — Vanderbilt University Medical Center
- Study coordinator: Gohar, Eman
Related research
Other NIH-funded projects on the same topics.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Coaching and Navigation by Community Health Workers via Telehealth for High-Risk Hypertension
A program using telehealth and community health workers to help adults with severe hypertension connect to primary care and follow practical, heart-healthy lifestyle tips.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Noninvasive portal pressure estimation using ultrasound-based subharmonic signals
A noninvasive ultrasound method to estimate portal vein pressure in adults with cirrhosis to help manage varices and ascites.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.