Understanding how esophageal cancer starts and changes the immune environment
Esophageal Squamous Cell Cancer Initiation and Immune Landscape Remodeling
['FUNDING_R01'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11005053
This study is looking at how esophageal cancer starts and changes the immune system, using special mice to understand the genetic changes involved, which could help find new ways to detect and treat this type of cancer earlier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11005053 on ClinicalTrials.gov |
What this research studies
This research investigates the initiation of esophageal squamous cell carcinoma (ESCC) and how it alters the immune landscape. Using a genetically engineered mouse model, researchers are exploring the genetic changes that lead to cancer and how these changes affect the immune response. By manipulating genes in esophageal organoids, they aim to identify key tumor suppressor genes involved in cancer development. This work could lead to better methods for early detection and treatment of ESCC.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for esophageal squamous cell carcinoma, such as those with a family history of the disease or certain pre-existing conditions.
Not a fit: Patients with other types of esophageal cancer or those who are not at risk for esophageal squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for esophageal cancer, potentially enhancing patient outcomes.
How similar studies have performed: Other research has shown promise in using genetic models to study cancer initiation, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, JAE-IL — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: PARK, JAE-IL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.