Understanding how ESBL E. coli affects the gut microbiome in infants
Official title: Investigating the impact of ESBL E. coli colonization on infant microbiome
Funded at Lurie Children's Hospital of Chicago · NIH-10884428 · Data updated 2026-11-12
This study is looking at how certain bacteria that can cause infections affect the gut health of babies, focusing on when these bacteria show up and how food might influence their impact on the gut.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $195,186 |
| NIH project number | 5R21AI178334-02 |
| Project ID | NIH-10884428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants who may be at risk of colonization by ESBL E. coli, particularly those born in settings where such bacteria are prevalent.
✕Less likely to help
Patients who are older than 21 years or those who have not been exposed to ESBL E. coli may not benefit from this research.
What this research studies
This research investigates the effects of colonization by extended spectrum beta-lactamase-producing E. coli on the gut microbiome of infants. It aims to understand how these bacteria, which can cause serious infections, impact the development of the gut microbiome during early life. The study will analyze the timing of colonization and the role of nutrition in shaping the microbiome. By using a murine model, researchers will explore how these bacteria persist in the gut and their potential long-term effects on health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing infections in infants and better understanding of gut health.
How similar studies have gone: Previous studies have shown that understanding gut colonization in early life can significantly impact health outcomes, indicating that this research builds on established findings.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Arshad, Mehreen — Lurie Children's Hospital of Chicago
- Study coordinator: Arshad, Mehreen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.