Understanding how errors in protein translation affect health and behavior
Regulation and Physiological Roles of Translational Fidelity
This study is looking at how our cells make proteins from our genes and what can go wrong when this process isn't accurate, which can lead to problems like bacterial infections or brain issues, and it's designed for anyone interested in understanding how these errors affect health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-11085831 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the accuracy of protein translation from genetic information, focusing on how environmental and genetic factors influence translational fidelity. By examining how these errors can lead to issues like bacterial growth defects and neurodegeneration in mammals, the study aims to uncover the physiological roles of translational fidelity. The research employs advanced technologies to screen for conditions that alter translational accuracy, providing insights at both population and single-cell levels. This could help in understanding how fluctuations in translation errors impact cell behavior and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases or conditions influenced by protein translation errors.
Not a fit: Patients with conditions unrelated to protein translation or those not experiencing neurodegenerative symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to protein misfolding and neurodegeneration.
How similar studies have performed: Other research has shown promising results in understanding the impact of translational fidelity on health, suggesting that this approach could yield valuable insights.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Ling, Jiqiang — Univ of Maryland, College Park
- Study coordinator: Ling, Jiqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.