Understanding how Epstein-Barr Virus may trigger multiple sclerosis
Official title: Deciphering the Role of Epstein-Barr Virus Molecular Mimicry and B cell Transformation in Multiple Sclerosis
Funded at Stanford University · NIH-10997373 · Data updated 2026-11-12
This study is looking at how the Epstein-Barr Virus might play a role in causing multiple sclerosis by changing certain immune cells, and it's for anyone interested in understanding more about how MS develops and progresses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 3, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $570,031 |
| NIH project number | 5R01AI173189-03 |
| Project ID | NIH-10997373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis who have a history of Epstein-Barr Virus infection.
✕Less likely to help
Patients who do not have multiple sclerosis or have not been infected with Epstein-Barr Virus may not benefit from this research.
What this research studies
This research investigates the connection between Epstein-Barr Virus (EBV) infection and the development of multiple sclerosis (MS). It focuses on how EBV may transform B cells in patients, leading to the activation of autoreactive T cells and the production of autoantibodies that contribute to MS pathology. The study will analyze the genetic and molecular mechanisms involved, aiming to identify specific disease subtypes associated with different immune responses. By examining these processes, the research seeks to uncover critical insights into MS development and progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating multiple sclerosis.
How similar studies have gone: Previous research has shown a strong correlation between Epstein-Barr Virus infection and multiple sclerosis, indicating that this approach is grounded in established findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Robinson, William H — Stanford University
- Study coordinator: Robinson, William H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.