Understanding how Epstein-Barr Virus causes lymphomas
Stringent Latent Epstein-Barr Virus (EBV) Infection Collaborates with Cellular Gene Alterations to Induce EBV+ Lymphomas
This research aims to understand how the Epstein-Barr virus (EBV) causes certain types of lymphoma, especially in people with AIDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11127525 on NIH RePORTER |
What this research studies
We want to learn how EBV leads to lymphomas like Burkitt, Hodgkin, and diffuse large B cell lymphomas, even when the virus doesn't express a key protein called EBNA2. We are using new laboratory models, including special cell cultures and a humanized mouse model, to see if a modified EBV can cause lymphoma. This will help us discover the exact steps the virus takes to trigger these cancers, particularly in the context of AIDS.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with EBV-positive lymphomas, particularly those also living with AIDS.
Not a fit: Patients whose lymphomas are not linked to Epstein-Barr virus may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new ways to prevent or treat EBV-related lymphomas by targeting the specific viral and cellular processes involved.
How similar studies have performed: This project uses novel laboratory models and a newly created virus mutant to explore a previously unstudied mechanism of lymphoma development.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kenney, Shannon Celeste — University of Wisconsin-Madison
- Study coordinator: Kenney, Shannon Celeste
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.