Understanding how Epstein-Barr Virus causes certain cancers
Epigenomic Drivers of EBV Epithelial Cancers
['FUNDING_P01'] · WISTAR INSTITUTE · NIH-11085159
This study is looking into how the Epstein-Barr Virus (EBV) might help certain cancers grow and change, with the goal of finding new ways to treat patients who have cancers linked to this virus.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11085159 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Epstein-Barr Virus (EBV) in the development of epithelial cancers by examining how the virus establishes a latent infection that influences cancer growth. The team will explore the mechanisms behind EBV's ability to maintain its presence in cancer cells and how this affects the cancer's genetic makeup, particularly focusing on DNA methylation patterns. By collaborating with other projects, they aim to uncover new therapeutic strategies that could target these latent infections and improve treatment options for patients with EBV-associated cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with EBV-associated epithelial cancers.
Not a fit: Patients with cancers not associated with Epstein-Barr Virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target EBV infections in cancer patients, potentially improving treatment outcomes.
How similar studies have performed: Previous research has shown promising results in targeting viral infections in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIEBERMAN, PAUL M. — WISTAR INSTITUTE
- Study coordinator: LIEBERMAN, PAUL M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Induction, Cancers