Understanding how Epstein-Barr virus becomes active
Regulation of the Epstein-Barr Virus Lytic Switch
This research explores how the Epstein-Barr virus, which causes various cancers and mononucleosis, switches from a quiet state to an active state in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11113885 on NIH RePORTER |
What this research studies
Epstein-Barr virus (EBV) is a common virus that stays in your body for life and can lead to conditions like mononucleosis and certain cancers. This project aims to understand the specific triggers that cause EBV to become active and multiply, a process called lytic replication. Researchers are using advanced genetic screening techniques to identify human genes that control this viral switch. By learning how the virus is regulated, we hope to find new ways to prevent it from causing disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies based on these findings may seek individuals with EBV-related conditions.
Not a fit: Patients seeking immediate treatment for active EBV infections or related cancers would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or prevention strategies for EBV-related diseases by targeting the virus's ability to reactivate.
How similar studies have performed: This project builds upon existing knowledge of EBV biology and uses established genetic screening methods to uncover novel host factors controlling viral reactivation.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gewurz, Benjamin Elison — Brigham and Women's Hospital
- Study coordinator: Gewurz, Benjamin Elison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.