Understanding how Epstein-Barr virus affects B-cells in the body
Exploiting Metabolism to Uncloak Epstein-Barr Virus Immunogens in Latently Infected B-cells
This study is looking at how the Epstein-Barr virus, which can cause mononucleosis and some cancers, hides in the tonsils and B-cells, and it aims to find ways to help the immune system fight it better, so it can help people affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897118 on NIH RePORTER |
What this research studies
This research investigates the Epstein-Barr virus (EBV), which is known to cause infectious mononucleosis and various cancers, particularly in B-cells. The study focuses on how the virus establishes a persistent infection in the tonsils and B-cell compartment, and how it evades the immune response. Using advanced techniques like CRISPR, researchers aim to uncover the mechanisms that regulate the viral genome and identify potential immunogenic proteins that could be targeted for treatment. By understanding these processes, the research seeks to improve strategies for combating EBV-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals over 21 years old who are infected with Epstein-Barr virus or have conditions related to it, such as Burkitt lymphoma or AIDS.
Not a fit: Patients who do not have Epstein-Barr virus infections or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response against EBV and reduce the incidence of related cancers.
How similar studies have performed: Previous research has shown promise in understanding EBV's role in B-cell malignancies, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Guo, Rui — Tufts University Boston
- Study coordinator: Guo, Rui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.