Understanding how epilepsy affects memory and spatial awareness
Circuits Driving Spatial Coding Deficits in Epilepsy
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11005217
This study is looking at how temporal lobe epilepsy affects memory and navigation in the brain by comparing brain activity in healthy people and those with epilepsy, to help understand why some people with epilepsy have trouble remembering things.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11005217 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of temporal lobe epilepsy (TLE) on memory and spatial coding by examining how specific brain circuits function in both healthy and epileptic models. Using advanced techniques like calcium imaging and silicon probes, the study aims to identify changes in brain cell activity and synchronization that contribute to memory impairments in epilepsy. By analyzing the connections between the medial entorhinal cortex and the hippocampus, the research seeks to uncover the underlying mechanisms of cognitive deficits associated with epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience memory and cognitive challenges.
Not a fit: Patients without a diagnosis of epilepsy or those who do not experience cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for memory impairments in patients with epilepsy.
How similar studies have performed: Previous research has shown promising results in understanding brain circuit dysfunctions in epilepsy, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHUMAN, TRISTAN — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SHUMAN, TRISTAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.