Understanding how epigenomics affects breast tumors in women with BRCA1 mutations.
Probing the role of epigenomics in Brca1-deficient mammary tumors.
This study is looking at how changes in certain genes might affect the growth of breast tumors in people with BRCA1 mutations, with the goal of finding better ways to predict and prevent cancer for those at higher risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-10793645 on NIH RePORTER |
What this research studies
This research investigates the role of epigenomics in the development of breast tumors in individuals with BRCA1 mutations. It aims to identify how changes in the epigenome can influence cancer susceptibility and tumor progression. By using innovative models of mammary oncogenesis, the study will explore specific epigenetic mechanisms that may contribute to the development of BRCA1-deficient tumors. This could lead to better predictive tools for those at higher risk and new strategies for prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who carry BRCA1 mutations and are at increased risk for developing breast cancer.
Not a fit: Patients without BRCA1 mutations or those who do not have a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting breast cancer risk and developing targeted prevention strategies for women with BRCA1 mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Dos Santos, Camila — Cold Spring Harbor Laboratory
- Study coordinator: Dos Santos, Camila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.