Understanding how epigenomic changes affect heart failure.
Epigenomic signaling and heart failure.
['FUNDING_R01'] · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · NIH-10528446
This study is looking at how certain changes in our cells can lead to heart failure, especially in people with dilated cardiomyopathy, and it aims to find new ways to help manage this condition by examining heart samples from both humans and animals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-10528446 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular and cellular mechanisms that lead to heart failure, particularly focusing on dilated cardiomyopathy, which is characterized by enlarged heart chambers and reduced heart function. The study utilizes advanced genome-scale high-throughput screening techniques to identify epigenetic regulators involved in the progression of heart failure. By examining both human and animal heart samples, the research aims to uncover critical factors that contribute to the transition from compensated heart function to decompensated heart failure. This could provide insights into new therapeutic targets for managing heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or those at risk of developing dilated cardiomyopathy.
Not a fit: Patients with heart failure caused by non-epigenetic factors or those who do not have dilated cardiomyopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of heart failure.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics in heart disease, indicating that this approach has potential for success.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, JIANG — TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Study coordinator: CHANG, JIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.