Understanding how epigenetics influences cell types in the colon
Official title: Epigenetic regulation of lineage specification in colon epithelial cells
Funded at University of Colorado Denver · NIH-11015822 · Data updated 2026-11-12
This study is looking at how certain changes in the way genes are turned on and off can influence how colon cells develop and specialize, which could help us understand more about colon health and diseases like cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $80,224 |
| NIH project number | 5F32DK135241-03 |
| Project ID | NIH-11015822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting colon health, particularly those with a history of colon cancer or other epithelial disorders.
✕Less likely to help
Patients with non-colon related health issues or those who do not have any epithelial cell disorders may not benefit from this research.
What this research studies
This research investigates how epigenetic changes, specifically the methylation of histone H3 at lysine 36, affect the differentiation and identity of colon epithelial cells. By studying the unique stem cells in the colon that regenerate every few days, the research aims to uncover the mechanisms that guide these cells to become specialized types, such as colonocytes and goblet cells. The study will utilize advanced techniques to analyze the methylation patterns and their functional implications on cell fate decisions. This could provide insights into how these processes may be altered in diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating colon-related diseases by targeting the mechanisms of cell differentiation.
How similar studies have gone: Previous research has shown promising results in understanding epigenetic regulation in other rapidly renewing tissues, suggesting potential for success in this area as well.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Meyer, Anne R. — University of Colorado Denver
- Study coordinator: Meyer, Anne R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.