Understanding how epigenetics controls sperm cell renewal in males
Official title: Epigenetic control of spermatogonial stem cell self-renewal
Funded at University of Pennsylvania · NIH-11065547 · Data updated 2026-11-12
This study is looking at how a certain factor in our genes helps control the growth of sperm-producing cells in men, which could lead to better understanding and treatments for male fertility issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 5, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $388,827 |
| NIH project number | 5R01HD109253-03 |
| Project ID | NIH-11065547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adult males experiencing fertility issues or those interested in understanding male reproductive health.
✕Less likely to help
Patients who are not male or those who do not have concerns related to fertility may not receive benefit from this research.
What this research studies
This research investigates the role of a specific epigenetic factor, DOT1L, in regulating the self-renewal of spermatogonial stem cells (SSCs) in adult males. By using a combination of genetic, chemical, and genomic approaches, the study aims to uncover the mechanisms that balance SSC self-renewal and differentiation, which are crucial for continuous sperm production. The findings could lead to advancements in reproductive health and fertility treatments. Patients may benefit from insights into male fertility and potential therapies derived from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for male infertility and improved understanding of sperm production.
How similar studies have gone: Other research has shown success in understanding stem cell regulation, but the specific focus on DOT1L in SSC self-renewal is a novel approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Wang, Peijing Jeremy — University of Pennsylvania
- Study coordinator: Wang, Peijing Jeremy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.