Understanding how epigenetics affects tissue regeneration
Delineating epigenetic coordination of regenerative cell plasticity
This study is looking at how certain genes help our body heal and repair skin and other tissues after injuries, especially by working with immune cells, which could lead to new treatments for wounds, lung problems, and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10913522 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic modifiers in the regeneration of epithelial tissues, which are crucial for healing and repair after injury. By examining how these modifiers interact with immune cells, the research aims to uncover the mechanisms that enable tissue restoration. The approach includes a novel in vivo gene editing platform to manipulate and study these interactions in real-time. This could lead to new therapeutic strategies for conditions like wound healing, lung diseases, and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions affecting epithelial tissues, such as wounds, lung diseases, or cancers.
Not a fit: Patients with non-epithelial tissue conditions or those not experiencing tissue regeneration issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance tissue healing and regeneration for various diseases.
How similar studies have performed: Previous research has shown promise in understanding epigenetic mechanisms in tissue regeneration, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Woappi, Yvon — Columbia University Health Sciences
- Study coordinator: Woappi, Yvon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.