Understanding how epigenetic regulators affect eye injuries from chemical exposure
The Role of Master Epigenetic Regulators in Ocular Chemical Injury
This study is looking at how mustard gas and nitrogen mustard can hurt the eyes, especially the cornea, and aims to find ways to help heal those injuries by understanding how these chemicals cause inflammation and other problems, which could lead to better treatments for anyone affected by chemical exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10896346 on NIH RePORTER |
What this research studies
This research investigates the impact of mustard gas and nitrogen mustard on eye injuries, particularly focusing on corneal damage. It aims to uncover the underlying mechanisms of inflammation, neovascularization, and fibrosis caused by these chemical agents. By studying the role of BET proteins, which are involved in gene regulation, the research seeks to identify potential therapeutic targets for managing ocular injuries resulting from chemical exposure. Patients may benefit from insights that could lead to improved treatments for chemical-induced eye injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced ocular injuries due to chemical agents, particularly mustard gas.
Not a fit: Patients with ocular injuries from non-chemical causes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from ocular injuries caused by chemical exposure.
How similar studies have performed: While the role of BET proteins in ocular chemical injury is not extensively studied, similar approaches in other areas of inflammation and fibrosis have shown promise.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Zhang, Wenbo — University of Texas Med Br Galveston
- Study coordinator: Zhang, Wenbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.