Understanding how epigenetic information influences gene function
Defining the mechanisms of epigenetic information flow
This study is looking at how the way our DNA is packaged in cells can change the way genes work, which is important for understanding how our bodies develop and how diseases can happen, helping us learn more about different health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10917067 on NIH RePORTER |
What this research studies
This research investigates the dynamic role of chromatin, which is the structure that packages DNA in the nucleus, in regulating gene function through epigenetic mechanisms. It aims to uncover how chemical modifications and noncoding RNA influence chromatin structure and, consequently, gene expression in various biological contexts, including development and disease. By studying these processes, the research seeks to provide insights into how cellular identity is maintained and altered, which could have implications for understanding various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by epigenetic factors, such as certain cancers or neurodevelopmental disorders.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to epigenetic changes.
How similar studies have performed: Other research has shown promising results in understanding epigenetic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Ruthenburg, Alexander Jackson — University of Chicago
- Study coordinator: Ruthenburg, Alexander Jackson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.